Pragathi Guruprasad was born to Guruprasad and Kanaka on 14 September 1997 in Singapore, and she has an elder sister, Saiprithvi. In Singapore, her father taught Carnatic lessons, and since at the age of five, Pragathi had also begun training in carnatic music. Her family subsequently relocated to Fremont, California where she continued learning Carnatic and Hindustani music from both her father at first and then from a teacher, Sangeetha Swaminathan, a disciple of Sudha Raghunathan.
In July 2014, she signed on to make her acting debut by portraying a supporting role in Bala‘s Tharai Thappattai (2016), but later opted out owing to her college commitments. In September 2016, Bala later announced that she would portray the lead role in his next project starring actor Yuvan. However the film was eventually shelved before production began.
In 2020, she made an appearance in a small role in the American comedy drama Never Have I Ever. Pragathi sang the popular Tamil Sangam poetry ‘Yayum Ngayum’ for the album Sandham: Symphony Meets Classical Tamil by Composer Rajan Somasundaram, which in July 2020, was featured in Amazon’s Top#10 International Music albums.
Pragathi has recently sung her first single In Europe, titled as Pattampoochi. Lyrics have been written by Jenitha Joseph. The music is by Kowtham Mohanarajan and the vocals are by Kadhalviruz and herself. This product is a result of work from 3 different countries (Denmark, Germany and America) and is also Pragathi’s first song in Europe. On August 27, 2013, her song “Aasai” with TeeJay, a London based singer, was released, receiving critical acclamation for her singing.